Sinemet (Carbidopa-Levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome.
Active substance: Carbidopa/Levodopa
Delivery to: USA
Oct 28th - Nov 06th (9-18 working days) by Airmail
Oct 24th - Oct 31st (5-12 working days) by EMS
Parkinson's disease is a progressive, neurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular system. Its characteristic features include resting tremor, rigidity, and bradykinetic movements. Symptomatic treatments, such as levodopa therapies, may permit the patient better mobility.
Mechanism of Action
Current evidence indicates that symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. Administration of dopamine is ineffective in the treatment of Parkinson's disease apparently because it does not cross the blood-brain barrier. However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa relieves symptoms of Parkinson's disease.
When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect, and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues.
Since levodopa competes with certain amino acids for transport across the gut wall, the absorption of levodopa may be impaired in some patients on a high protein diet.
Carbidopa inhibits decarboxylation of peripheral levodopa. It does not cross the blood-brain barrier and does not affect the metabolism of levodopa within the central nervous system.
The incidence of levodopa-induced nausea and vomiting is less with SINEMET than with levodopa. In many patients, this reduction in nausea and vomiting will permit more rapid dosage titration.
Since its decarboxylase inhibiting activity is limited to extracerebral tissues, administration of carbidopa with levodopa makes more levodopa available for transport to the brain.
Carbidopa reduces the amount of levodopa required to produce a given response by about 75% and, when administered with levodopa, increases both plasma levels and the plasma half-life of levodopa, and decreases plasma and urinary dopamine and homovanillic acid.
The plasma half-life of levodopa is about 50 minutes, without carbidopa. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
In clinical pharmacologic studies, simultaneous administration of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine than administration of the two drugs at separate times.
Pyridoxine hydrochloride (vitamin B6), in oral doses of 10 mg to 25 mg, may reverse the effects of levodopa by increasing the rate of aromatic amino acid decarboxylation. Carbidopa inhibits this action of pyridoxine; therefore, SINEMET can be given to patients receiving supplemental pyridoxine (vitamin B6).
Sinemet uses are primarily concerned with treating Parkinson's disease and Parkinson-like symptoms. This eMedTV page takes an in-depth look what Sinemet is used for, including how it works to increase dopamine levels and possible off-label uses.
The typical recommended starting Sinemet dosage is 25-100 mg three times daily. As this eMedTV article explains, the recommended dose will vary, depending on factors such how you respond to Sinemet and other medications you are taking.
Sinemet Drug Interactions
Medicines that may cause Sinemet drug interactions include blood pressure medicines and antipsychotic drugs. This eMedTV segment lists other medicines that may interact with Sinemet and explains what can happen when these medicines are combined.
Sinemet Warnings and Precautions
This eMedTV page outlines several important Sinemet warnings and precautions. For example, you should not use the drug if you have narrow-angle glaucoma or a history of melanoma. This page also explains what to tell your doctor before taking it.
This eMedTV resource explains that vomiting, confusion, and a rapid heart rate are possible effects of a Sinemet (carbidopa-levodopa) overdose. This page lists other symptoms that may occur and describes various treatment options that are available.
Sinemet and Pregnancy
This page from the eMedTV Web site explains that information from animal studies on Sinemet (carbidopa-levodopa) and pregnancy indicates that the drug may not be safe for pregnant women. For example, the drug may increase the risk of birth defects.
Sinemet and Breastfeeding
This eMedTV Web article explains that Sinemet (carbidopa-levodopa) does pass through breast milk. As a result, it may negatively affect a woman's ability to breastfeed. It is not known what effects the medication might have on a nursing infant.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Sinemet:
Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Sinemet:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; new or increased involuntary movements; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred or double vision); yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
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|Country||Shipping Method||Tracking||Delivery time||Delivery to||Price|
|Registered Airmail||Delivery Report only (where available). Each parcel is dispatched with unique Tracking ID which may be later used via Track-Trace service||Oct 28th - Nov 06th
9-17 working days
|EMS||Tracking report (where available). Each parcel is dispatched with unique Tracking ID which may be later used via Track-Trace service||Oct 24th - Oct 31st 5-13 working days||Mailbox||$29.99 each 120 pills|